PENGARUH PEMBERIAN VIRGIN COCONUT OIL TERHADAP KADAR TRIGLISERIDA DAN KOLESTEROL TOTAL DARAH TIKUS WISTAR SETELAH DIINDUKSI ATEROGENESIS

Abstract

Background: Virgin Coconut Oil (VCO) – Healthy co. have a lot of saturated fatty acid, dominated with Medium Chain Fatty Acid (MCFA) especially lauric acid. In body, MCFA directly enter to portal circulations and convert into energy Adenosin Tri Phosphate (ATP). The objective of this study is to prove if virgin coconut oil can influence the trigliseride and total cholesterol serum of wistar after induction of atherogenesis. Method: An experimental study using post test only control group design. The sample were 16 male aged 20 weeks Wistar, with simple random sampling allocated into two groups (group I and II). Group I as control and group II that was treatment group, given vco with a dose of 0,00345ml/gr BW. On the 56th day, the blood were taken from all wistar then have measured. The collected data was primary data from the result of measurement of trigliseride serum with GPO methode and total cholesterol with CHOD-PAP method.This data were analyzed by independent T-test. Result: It was shown in this study that the trigliseride and total cholesterol serum of the treaten group was significantly lower than control (p<0,01). Conclusion: The administering of vco in 4 weeks can decrease the trigliseride and cholesterol total serum of wistar by the dose of 0,00345 ml/grBW/day. Keyword: Virgin Coconut Oil, Medium Chain Fatty Acid, Atherogenesis, Trigliseride serum and Total Cholesterol Serum