PENGARUH PEMBERIAN PROPOXUR TERHADAP GAMBARAN HISTOPATOLOGI DUODENUM MENCIT BALB/C

Abstract

Background : Propoxur is the carbamat group that often used for pesticide in the farm as insecticide, fungicide, herbicide, nematocide and also for suicide purpose. Some scientist reveal that pesticide from this group if used will be distributed quickly to organ and tissue. Objective : to examine and to score the histological appearance of Balb/c mice small intestine given oral administration of graded dose Propoxur. Method : The Experiment used The Post Only Control Group Design. There are 4 groups with 10 sample of mice each groups so there are total of 40 Balb/c male mice, with age of 8-9 weeks and weight of 20-25 gram. K is the control group, without being given any Propoxur. P1 is mice being given Propoxur orally ½ x 37mg KgBW. P2 is mice being given Propoxur orally 37mg/KgBW. P3 is mice being given Propoxur orally 2 x 37 mg/KgBW. Result : The adminestering of Propoxur altering the histological appearance of Balb/c mice’small intestine which is desquamasi, erosi, ulceration. On statistical test of scoring small intestine damage there are significant differences between each groups with control and either between each groups one another. Conclusion : The Propoxur given orally with graded doses are significantly affects the damage done to the epitelial mucose of Balb/c mice small intestine. Keywords : Propoxur, small intestine, the integrity of epitelial mucose.