PENGARUH PEMBERIAN PROPOXUR DOSIS BERTINGKAT PER ORAL TERHADAP GAMBARAN HISTOPATOLOGI LAMBUNG MENCIT Balb/c

Abstract

Background: Propoxur is a pesticide commonly used in the field of agriculture as well as health. However, nowadays it is also commonly used in the cases of suicide attempt. Intoxication signs and symptoms include nausea, vomiting, abdominal cramps, sweating, diarrhea, excessive salivation. Objective: To find the correlation of histopathological level on Balb/c mice’s stomach with oral administration of graded dose Propoxur l8,5 mg, 37 mg and 74 mg respectively. Method: This experimental study with post test only control group design used 40 Balb/c male mice which were divided into 4 groups. Group K received no Propoxur and was treated as control. Group P1 treated with l8,5 mg Propoxur (half letal dose). Group P2 treated with 37 mg Propoxur ( letal dose). Group P3 treated with 74 mg Propoxur (double letal dose ). Result: Mean score of epithelial integrity of stomach from four groups was significantly different ( p=0,000). Mean score of epithelial integrity of stomach from control was the lowest (0,37 + 0,08), and P3 is the higest (2,80 + 0,18). P3 had the higest median, and the lowest is the control group. Conclusion: There were histopathological level difference on Balb/c mice’s stomach with oral administration of Propoxur between untreated group and Propoxur-treated groups, and between each graded dose Propoxur-treated groups. The histopathological level changes of epitel mucous of stomach Balb/c mice. Keywords: Propoxur, stomach erosion, mucous epithelial intregity