Dwiputro, Bagus_Anggoro (2006) PENGARUH PEMBERIAN JUS LIDAH BUAYA (Aloe vera Linn)TERHADAP KADAR KOLESTEROL TOTAL SERUM TIKUS JANTAN STRAIN WISTAR HIPERLIPIDEMIA. Undergraduate thesis, Faculty of Medicine.
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Abstract
PENGARUH PEMBERIAN JUS LIDAH BUAYA (Aloe vera Linn)TERHADAP KADAR KOLESTEROL TOTAL SERUM TIKUS JANTAN STRAIN WISTAR HIPERLIPIDEMIA Endang Sri Sunarsih* , Bagus Anggoro Dwiputro ** Latar belakang : Lidah buaya atau Aloe vera merupakan tanaman yang telah diketahui memiliki khasiat pengobatan. Salah satu manfaat tanaman lidah buaya adalah sebagai antihiperlipidemia. Aloe vera mengandung asam nikotinat (vitamin B3), vitamin C, anthraquinon, asam folat, selenium, magnesium, enzim lipase dan lignin yang bisa menurunkan kadar kolesterol dalam darah. Tujuan penelitian ini adalah untuk mengetahui pengaruh jus lidah buaya dengan berbagai dosis terhadap kadar koleterol total serum pada tikus hiperlipidemia. Metoda : Penelitian ini merupakan penelitian experimental dengan rancangan Pre and Post Randomized Controlled Group Design pada 24 ekor tikus wistar jantan yang dibagi menjadi 4 kelompok. K merupakan kelompok kontrol, sedangkan untuk 3 kelompok perlakuan masing-masing diberi jus Aloe vera dengan dosis 2ml/hari, 3ml/hari dan 4ml/hari selama 15 hari. Analisis kadar kolesterol total serum menggunakan metode CHOD-PAP. Data yang diperoleh dianalisis menggunakan uji t berpasangan dan one way anova dengan SPSS 13.00 for Windows Hasil : Pemberian jus Aloe vera pada kelompok perlakuan menyebabkan penurunan kadar kolesterol total serum yang bermakna (p=0,000) pada semua dosis dibanding kontrol. Dosis optimal didapatkan pada dosis 4 ml/hari karena dapat menurunkan kadar kolesterol total paling maksimal. Kesimpulan : Pemberian jus Aloe vera 2 ml/hari, 3 ml/hari dan 4 ml/hari selama 15 hari dapat menurunkan kadar kolesterol total serum tikus hiperlepidemia secara bermakna dengan dosis optimal 4 ml/hari Kata kunci : Hiperlipidemia, kolesterol total, jus lidah buaya The Effect of Orally Administered Aloe vera Linn. Juice on Total Cholesterol Serum Level in Hiperlipidemic Wistar Rats Endang Sri Sunarsih*, Bagus Anggoro Dwiputro ** Background: Aloe vera has been known as medical plant. One of Aloe vera’s benefits is antihiperlipidemic. Aloe vera contains nicotinat acid (vitamin B3), vitamin c, folic acid, selenium, magnesium, lipase enzyme, lignin and anthraquinon that can decrease cholesterol level on plasma. The aim of this study is to determine the effect of different proportion of Aloe vera juice on total cholesterol serum level in hyperlipidemic rats. Methods: An experimental study with pre and post test control group design consist of 24 male Wistar rats which are devided into 4 groups. K was control group, whereas three treatment groups are given diet containing 2 ml, 3 ml and 4 ml Aloe vera juice every day for 15 days. Total cholesterol serum level was determined using method CHOD-PAP. Data were analyzed using paired t-test and one way anova with SPSS 13.00 for Windows. Results: The administration of three dosage of Aloe vera juice significantly decreased (p=0,000) the total cholesterol serum level. The optimal dosage is 4 ml/day because it could decrease total cholesterol serum more than the other dosage. Conclusion: The administration of 2 ml/day, 3 ml/day and 4 ml/day of Aloe vera juice significantly decreased the total cholesterol serum level in hyperlipidemic rats with the optimal dosage is 4 ml/day Keyword: Aloe vera juice, total cholesterol, hyperlipidemic
Item Type: | Thesis (Undergraduate) |
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Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | Faculty of Medicine > Department of Medicine Faculty of Medicine > Department of Medicine |
ID Code: | 20382 |
Deposited By: | INVALID USER |
Deposited On: | 13 Aug 2010 10:51 |
Last Modified: | 13 Aug 2010 10:51 |
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