KADAR C-REACTIVE PROTEIN ANAK KANDUNG DARI PENDERITA DENGAN DAN TANPA PENYAKIT JANTUNG KORONER C-REACTIVE PROTEIN LEVELS IN CHILDREN OF PATIENTS WITH AND WITHOUT CORONARY HEART DISEASE

Abstract

Background: Coronary heart disease has become the main cause of death worldwide, with atherosclerosis which is a chronic inflamation as the hiden background. CRP (C-reactive protein), an acute phase protein, appear in coronary heart disease. Many researches try to find the relation of CRP and coronary heart disease, but they rarely measure the CRP in children of coronary heart disease patients. Aims: To analyse the means CRP levels in children of patients with or without coronary heart disease, and to find the influence of coronary heart disease patients to their children’s CRP levels after controlled by body mass index and lipid profile. Material and Methods: A cross sectional approach to 20 blood specimens from each group, children of patients with and without coronary heart diasease. CRP levels Means measured twice in range of 2 weeks, using hs-CRP PETIA technique, analysed with Mann-Whitney test and logistic regression. Result: Median CRP levels in children of coronary heart disease patients 2,15 (1,3-7,5), without coronary heart disease 1,48 (1,0-3,2), p=0,001. The proportion of parents with coronary heart disease to high CRP level in their own children 87%. Logistic regression analyse: parents with coronary heart disease has no influence to high CRP level 95%CI (0,49-55,82) Conclusions: CRP levels in the children of patients with coronary heart disease higher than those without coronary heart disease. There is no influence of coronary heart disease in patients to CRP levels of their own children. Suggestion: A similiar research is needed, by concerning more complex inflamation factors Latar belakang: Penyakit jantung koroner (PJK), penyebab kematian utama di dunia dengan aterosklerosis sebagai penyebab tersembunyi merupakan inflamasi kronik. CRP (C-reactive protein), suatu protein fase akut didapatkan pada PJK. Penelitian yang menghubungkan CRP dan PJK sudah banyak, tetapi penelitian CRP anak dengan riwayat orang tua PJK masih jarang. Tujuan penelitian: Menganalisis perbedaan rerata kadar CRP anak kandung penderita dengan dan tanpa PJK serta pengaruh orang tua PJK terhadap kadar CRP anak kandung setelah dikontrol dengan IMT (indeks masa tubuh) dan profil lipid. Material dan metoda: Pendekatan belah lintang, masing-masing 20 spesimen darah anak kandung penderita PJK dan tanpa PJK. Diukur rerata kadar CRP pada dua kali pemeriksaan dengan interval dua minggu, menggunakan metoda hs-CRP teknik PETIA dan analisis statistik uji beda Mann-Whitney serta regresi logistik. Hasil: Median kadar CRP anak kandung penderita PJK 2,15 (1,3-7,5), tanpa PJK 1,48 (1,0-3,2), p=0,001. Proporsi orang tua PJK dengan kadar CRP yang tinggi pada anak kandung 87%. Analisis regresi logistik: Orang tua PJK tidak berpengaruh terhadap kadar CRP yang tinggi 95%CI (0,487 – 55,821) Simpulan: Kadar CRP anak kandung penderita PJK lebih tinggi dibanding tanpa PJK. Tidak ada pengaruh orang tua PJK terhadap kadar CRP anak kandung Saran: Perlu dilakukan penelitian serupa dengan memperhatikan faktor inflamasi kronik yang lebih kompleks.