Immunological aspects of persistent hepatitis B in children

Notoatmojo, Harsoyo (2001) Immunological aspects of persistent hepatitis B in children. Paediatrica Indonesiana, 41 (7-8). pp. 208-213. ISSN 0030-9311


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We studied the immunological status of 203 children having persistence Hepatitis B (positive HBsAg) ranging in age from 6 to 14 years in Semarang Municipality. The results of humoral immunity examination (IgM Anti-HBc) showed that all were negative, indicating that they are not in acute phase of hepatitis B infection. Cellular immunity examination, i.e., CMI skin test has shown positive result in 64.9% on persistent and 65.2% in non persistent hepatitis B (p>0.05). T cell examination showed statistically significant difference (p<0.01) between persistenct and non persistent hepatitis B patients, there was is also significant difference (p<0.01) on CD4 cell examination. These findings indicated that there was difference in immunoregulation function and response repression of antivirus between both groups of patients. On the other hand CD4/ CD8 ratio and T cell function showed no significant difference between the two gorups of patients; similarly the specific function of cytotoxic T cell was not significantly difference.

Item Type:Article
Uncontrolled Keywords:persitent hepatitis-B, humoral immunity, immunoregulation, children
Subjects:R Medicine > R Medicine (General)
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:1660
Deposited On:12 Nov 2009 13:33
Last Modified:12 Nov 2009 13:33

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