The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome

Suharti, Catharina and Gorp , Eric C.M. van and Setiati , Tatty E. and Dolmans, Wil M.V. and Djokomoeljanto, Robert J. and Hack, C. Erik and Cate, Hugo ten and Meer, Jos W.M. van der (2002) The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome. Thromb Haemost, 87 . pp. 42-46.


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In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation (F1+2 and TATc) and fibrinolysis (t-PA, PAPc, and D-dimer). We found that TNF-, IL-1 and Il-1Ra, but not IL-6, concentrations were elevated in the circulation during the early stage of infection and at discharge from hospital. TNF- was significantly associated with D-dimer, an activation marker of fibrinolysis (p < 0.003), but not with activation markers of coagulation. IL-1 was significantly associated with t-PA (p < 0.03). IL-1Ra was significantly associated with F1+2, TATc (p < 0.04 and p < 0.02, respectively), whereas IL-6 was significantly associated with both, activation markers of coagulation (F1+2; p < 0.03) and fibrinolysis (PAPc; p = 0.002). Our data are in line with studies in bacterial sepsis. In severe dengue virus infection the same cytokines are involved in the onset and regulation of hemostasis.

Item Type:Article
Uncontrolled Keywords:Cytokines, coagulation, fibrinolysis, dengue shock syndrome
Subjects:R Medicine > R Medicine (General)
Divisions:Faculty of Medicine > Department of Medicine
Faculty of Medicine > Department of Medicine
ID Code:1633
Deposited By:Mr. Kedokteran Admin
Deposited On:09 Nov 2009 12:08
Last Modified:09 Nov 2009 12:08

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