KADAR GULA DARAH DAN KADAR HORMON TESTOSTERON PADA PRIA PENDERITA DIABETES MELITUS HUBUNGANNYA DENGAN DISFUNGSI SEKSUAL DAN PERBEDAANNYA DENGAN YANG TIDAK MENGALAMI DISFUNGSI SEKSUAL BLOOD GLUCOSE AND TESTOSTERONE HORMONE LEVELS IN MEN DIABETES MELLITUS PATIENT The Correlation With Sexual Dysfunction and Difference With Not Sexual Dysfunction

Abstract

Latar belakang : Diabetes melitus sering mempengaruhi potensi seksual pria. Sekitar 50 % pasien diabetes pria mengalami disfungsi ereksi dan 30 % penurunan libido, salah satunya disebabkan menurunnya kadar testosteron. Tujuan : Membuktikan hubungan kadar gula darah, hormon testosteron dan fungsi seksual pada pasien pria diabetes melitus dan mengetahui perbedaan kadar gula darah, hormon testosteron pada pasien yang mengalami dan yang tidak mengalami disfungsi seksual. Design penelitian : Observasional analitik dengan pendekatan belah lintang diteliti pada 40 pria diabetes melitus tipe 2 dengan usia 20-25 tahun,beristri dan aktif secara seksual, tensi ≤ 139/89 mmHg, bebas penyakit sistemik, tidak terdapat gangguan psikis. Gula darah diperiksa dengan metode glucose oxidase, testosteron ; radioimunoassay, hambatan libido ; ISD Quiz, kemampuan ereksi ; IIEF-5, screening depresi ; SRDS, retinopati ; opthalmoscopy, dan data demograpi umur, lama menderita, pendidikan, pekerjaan, penghasilan dan keteraturan minum obat dengan kuesioner tertutup. Analisis statistik : Univariat, uji korelasi Spearman’s rho dan uji t sampel tidak berpasangan dengan α 0,005. Hasil : Uji korelasi menunjukan hubungan signifikan antara kadar gula darah puasa dengan : testosteron (r=-0,536,p=0,001), hambatan libido (r=0,462,p=0,003), kemampuan ereksi (r=-0,536,p=0,000), ada hubungan gula darah 2 jam pp dengan : testosteron (r=0,514,p=0,001), hambatan libido (r=0,412,p=0,008), kemampuan ereksi (r=-0,481,p=0,002), ada hubungan kadar testosteron dengan : hambatan libido (r=-0,585, p=0,000), kemampuan ereksi (r=0,550,p=0,000). Uji t menunjukan perbedaan rerata signifikan antara gula darah puasa dengan : hambatan libido (p=0,000), kemampuan ereksi (p=0,000), antara gula darah 2 jam pp dengan : hambatan libido (p=0,036), kemampuan ereksi (0,005), antara testosteron dengan : hambatan libido (p=0,000), kemampuan ereksi (p=0,00) Simpulan : Ada hubungan antara kadar gula darah, hormon testosteron dengan fungsi seksual dan ada perbedaan kadar gula darah dan hormon testosteron antara penderita yang mengalami disfungsi seksual dengan yang tidak mengalami disfungsi seksual. Background : Diabetes mellitus often cause bad effect to potencies of men sexual. About 50 % men diabetes patient’s experienced erection dysfunction and 30 % experience libido descent, on of them cause of descending testosterone levels. Aim : Gave evidence correlation among blood glucose, testosterone hormone level and sexual function in men patient with diabetes mellitus and to know differential between blood glucose, testosterone hormone on the patient who experienced sexual dysfunction and not experienced it. Research design : Analitic observation by cross sectional approach, study in 40 men, diabetes mellitus type 2 for 20-25 years old, married and sexually active, blood pressure ≤ 139/89 mmHg, free from systemic disease, not contained psychologies disturbance. Blood glucose inspected by glucose oxidase method, testosterone ; radioimmunoassay, libido inhibited ; ISD Quiz, erection ability ; IIEF-5, screening depression ; SRDS, retinopathy ; opthaalmoscopy, and demography data ;age, suffered period, education, occupation, earning and regularity to take medicine by close questionnaire. Statistic Analysis : Univariat, correlation test of Spearmen’s rho.and t test sampling not paired with α 0,005. Result : Correlation test show the significant correlation between fasting blood glucose level with testosterone (r=-0,536,p=0,001),libido inhibited (r=0,462,p=0,003) erection ability (r=-0,536,p=0,000), present correlation between blood glucose 2 hour postprandial with testosterone level (r=0,514,p=0,001), libido inhibited (r=0,412,p=0,008), erection ability (r=-0,481,p=0,002), there are correlation between testosterone level and libido inhibited (r=-0,585, p=0,000), erection ability (r=0,550,p=0,000). t test showed significant mean difference among fasting blood glucose with libido inhibited (p=0,000), with erection ability (p=0,000), among blood glucose 2 our pp with libido inhibited (p=0,036) with erection ability (0,005), among testosterone with libido inhibited (p=0,000), with erection ability (p=0,00). Conclusion : Significant correlation between blood glucose, testosterone hormone level by sexual function and significant difference blood glucose and testosterone hormone level between patient who experienced and who not experienced sexual dysfunction.