Sindrom Stevens-Johnson dan Nekrolisis Epidermal Toksis di RSUP MH Palembang Periode 2006 - 2008

Abstract

Steven-Johnson syndrome and toxic epidermal necrolysis in RSUP MH Palembang in year 2006-2008 Background: Stevens-Johnson syndrome (SSJ) and toxic epidermal necrolysis (TEN) are rare, life-threatening, drug-induced cutaneous reactions. Methods: We conducted a retrospective study by gathering 43 SJS, SJS/TEN, and TEN patients data from RSUP MH General Hospital Palembang from 2006-2008. Variable that were evaluated covered the age, gender, incidence, drug causes, and results of medical treatment. Results: The number of SSJ cases was higher than SJS/TEN and TEN cases, most of SSJ patients were in 26-36 year age group (11 patients or 25.5%), with male/female ratio of: 55.8%:44.2%. The use of paracetamol, amoxycilline, tetracycline, cotrimoxsazole, methampirone, ciprofloxacine, and carbamazepine was associated with large increases in the risk of SSJ or TEN. Hospital stays for SSJ was 8.91 ± 5.52 days, and 13.2 ± 3.89 days for SJS/TEN. This retrospective study expressed the high incidence of the SJS in RSUP MH in 2006-2008 period, compared with the incidence reported in the bibliography. Conclusions: Although there were still controvercies in systemic corticosteroid use, this study showed the use of steroid gave satisfactory results.