Pengaruh Pemberian Jus Jambu Biji (Psidium Guajava L)Terhadap Volume Kaki dan Kadar Ion Nitrit Adjuvant Induced Arthritis Tikus Wistar

Abstract

The effect of Psidium Guajava L juice on nitric ion level and swelling of the joint in adjuvant induced arthritis rats Backgraund: Nitric oxide increases in adjuvant induced arthritis. It has been associated with the activities of nitrite oxide mediates inflammation and axidant, it is a progressive joint disease. Characterized by swelling of the joint associated with an destruction of bone and cartilage. Jambu biji (Psidium Guajava L) is known to be the source of antioxidant and antiinflamation. Aim: To find out the difference volume joint and nitrite ion in adjuvant induced arthritis rats after administration of jambu biji (Psidium Guajava L) juice. Methods: An experimental study had been done using a randomized post test only control group. Twenty five Wistar rats were divided into 5 group. 2 control groups (K- and K+) and 3 treated groups (jambu biji juice 1 g/day, 2 g/day and 3 g/day). Volume joint to assay mercury placement pletismography Griess was used to assay nitrite ion (activity NO) serum. One Way Anova test and mann Withney test were applied for data analysis. Results: A significant difference in volume joint between the treated groups. A significant different nitrite ion was found among the treated groups (p<0.05), but not between the K+ group and 2 g/day in 3 cc treated group. Conclusions: Jambu biji (Psidium Guajava L) juice shows an effect for volume joint and nitrite ion in consentration in adjuvant induced arthritis.