Dislipidemia dan Oval Fat Bodies Dalam Urin

Abstract

Dyslipidemia and oval fat bodies in urine Background: Lipid profiles such as cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol screening are expensive. Oval fat bodies (OFB) an epithelial tubulus cell within lipid degenerated/macrophag contains fat granule, is a marker of lipiduria will be expected as a feature of serum lipids and may be performed as a simple non invasive, inexpensive laboratory test. The aim of the study was to analyze the correlation between dyslipidemia and OFB. Methods: This study was performed in 66 male and female subjects of hypercholesterolemia and hypertriglyceridemia of 20-83 years old, which come to a private laboratory in Semarang within 3 months. Sample were taken purposively. The method used in detecting lipids serum was enzymatics (CHOD-PAP for cholesterol and GPO enzymatic for triglyceride) and OFB examination in urine using Sternheimer–Malbin staining. Results: Triglyceride and cholesterol mean value were 210.8 mg/dl (±131.74) and 230.6 mg/dl (±36.4). OFB were found in the urine of on 15 subjects (75%) with hyperlipidemia, 26 subjects (72.2%) with hypercholesterolemia and 6 subjects (70%) with hypertriglyceridemia. There were corellations between hypercholesterolemia and hypertriglyceridemia and OFB (r1=0.82, p1=0.01; r2=0.84, p2=0.05; r3=0.75, p3=0.05). Conclusions: There are positive correlation between dyslipidemia and the presence of OFB in urine.