Perubahan Kadar Hormon Tiroid pada Penderita Sindroma Nefrotik

Abstract

Thyroid hormones levels in nephrotic syndrome Background: Nephrotic syndrome is one of the most found kidney disease. A great part (>99%) of circulating thyroid hormones were bound to proteins, thus derangements of blood proteins in nephrotic syndrome are potential to disturb thyroid hormones levels. This study was aimed to compare thyroid hormones levels changes in childhood Nephrotic Syndrome before and after remission. Method: Thirty four nephrotic syndrome patients studied on Department of pediatric of Dr. Kariadi Hospital, Semarang between April 1995 to June 1996 were for albumin, cholesterol, thyroid and thyroid stimulating hormone levels before and after remission and were tested with Wilcoxon signed rank test. The correlation between albumin and thyroxin levels before and after remission. were analyzed with Spearman correlation test. Results: T4 level before remission was 26.89±16.12 nmol/L, TSH 9.36±5.51 IU/ml, and after remission T4 106.63±28.02 nmol/L,TSH 1.78±1.91 􀈝IU/mL. There were significant changes of thyroid hormones levels before and after remission (z=5.09; p=0.000). There were positive correlation between blood protein (albumin) level and thyroid hormone (T4) level in nephrotic syndrome before remission (r=0.51; p=0.000) and after remission (r=0.38; p=0.004). A great proportion of nephrotic syndrome patients, suffered from hypothyroidism and return to euthyroid after remission. Conclusions: Thyroid hormone levels changed during the course of nephrotic syndrome.