PERBEDAAN PENINGKATAN KADAR IODIUM DALAM URIN ANTARA ANAK SEKOLAH DASAR YANG ASCARIASIS DAN TIDAK ASCARIASIS SETELAH PEMBERIAN KAPSUL IODIOL Studi di Kecamatan Pakis Kabupaten Magelang THE DIFFERENCE OF URINARY EXCRETION IODINE (UEI) INCREASE BETWEEN PRIMARY SCHOOL CHILDREN WITH AND WITHOUT ASCARIASIS AFTER ADMINISTRATION OF ORAL IODIZED CAPSULE Study in Kecamatan Pakis Kabupaten Magelang

Prameswari, Galuh Nita (2005) PERBEDAAN PENINGKATAN KADAR IODIUM DALAM URIN ANTARA ANAK SEKOLAH DASAR YANG ASCARIASIS DAN TIDAK ASCARIASIS SETELAH PEMBERIAN KAPSUL IODIOL Studi di Kecamatan Pakis Kabupaten Magelang THE DIFFERENCE OF URINARY EXCRETION IODINE (UEI) INCREASE BETWEEN PRIMARY SCHOOL CHILDREN WITH AND WITHOUT ASCARIASIS AFTER ADMINISTRATION OF ORAL IODIZED CAPSULE Study in Kecamatan Pakis Kabupaten Magelang. Masters thesis, PROGRAM PASCASARJANA UNIVERSITAS DIPONEGORO .

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Abstract

Background: The distribution of iodized capsule is one of government means to prevent and ward off IDD (Iodine Deficiency Disorders). One of factors which could disturb absorption of iodized capsule in intestines is existence of Ascaris lumbricoides infestation. Pakis sub district of Magelang district form a severe endemic area (TGR 30%). Ascariasis prevalence in the mentioned area is quite advance (47,5%). The objective of this study is to find out the difference of Urinary Excretion Iodine (UEI) increase between primary school children with and without Ascariasis after administration of oral iodized capsule, in Pakis subdistrict of Magelang district. Method of study: This study used pretest-posttest design. The subjects were divided into two group, they were Ascariasis group and without Ascariasis group, then all of subjects in both groups got iodized capsule. Urinary Iodine Excretion (UEI) content was measured before and two weeks after administration of iodized capsule. Independent samples t-test used for the statistics test. Result of study: Mean of UEI content before administration of iodized capsule on without Ascariasis group was lower (62,7 pg/L ± 47,5 pg/L) than Ascariasis group (90,7 pg/L ± 55,1 pg/L). However, after administration of iodized capsule, UEI content on without Ascariasis group became higher (469,8 pg/L ± 73,9 pg/L) than the Ascariasis group (437,6 pg/L ± 137,7 pg/L). The urinary excretion iodine increase (delta of UEI content before and after administration of oral iodized capsule) on without Ascariasis group was higher (407,1 pg/L ± 89,9 pg/L) than Ascariasis group (346,9 pg/L ± 135,9 pg/L) and the difference between both groups was significant (p=0,036*). Conclusion: The existence of Ascaris lumbricoides infestation in the intestines cause interference of iodine absorption, which finally make the low urinary excretion iodine content. Recommendation: For children who have high risk to get infected of Ascariasis, should to give anthelminthic continually once a month. The therapy could be held self-supporting by school, with paying two thousands rupiah per month, each student would get anthelminthic every month from local central public health. The distribution of oral iodized capsule for school children with appropriate recommendation dose, preferable constantly done until the endemic decrease. Latar Belakang: Salah satu upaya yang dilakukan pemerintah untuk pencegahan dan penanggulangan GAKI (Gangguan Akibat Kekurangan lodium), yaitu dengan distribusi kapsul iodiol. Salah satu faktor yang dapat mengganggu penyerapan kapsul iodiol di dalam usus yaitu adanya infestasi cacing Ascaris lumbricoides. Kecamatan Pakis Kabupaten Magelang merupakan daerah endemis berat (TGR ?..30%). Prevalensi Ascariasis di daerah tersebut cukup tinggi, yaitu 47,5%. Tujuan penelitian ini adalah untuk mengetahui perbedaan peningkatan kadar iodium dalam urin (UEI) antara anak Sekolah Dasar yang Ascariasis dan tidak Ascariasis setelah pemberian kapsul iodiol di Kecamatan Pakis Kabupaten Magelang. Metode Penelitian: Penelitian ini menggunakan pretest-posttest design. Subyek dibagi menjadi dua kelompok, yaitu kelompok Ascariasis dan tidak Ascariasis, kemudian semua subyek diberi kapsul iodiol. Pengukuran kadar UEI dilakukan sebelum dan dua minggu setelah pemberian kapsul iodioi. Uji statistik yang digunakan, yaitu independent samples t-test. HasH penelitian: Rata-rata kadar iodium urin sebelum pemberian kapsul iodiol pada kelompok tidak Ascariasis lebih rendah (62,7 pg/L ± 47,5 pg/L) daripada kelompok Ascariasis (90,7 pg/L ± 55,1 pg/L). Namun setelah pemberian kapsul iodiol, rata-rata kadar iodium urin pada kelompok tidak Ascariasis menjadi lebih tinggi (469,8 pg/L ± 73,9 pg/L) daripada kelompok Ascariasis (437,6 pg/L ± 137,7 pg/L). Rata-rata peningkatan kadar UEI (selisih kadar UEI sebelum dan setelah pemberian kapsul iodiol) pada kelompok tidak Ascariasis lebih tinggi (407,1 pg/L ± 89,9 pg/L) daripada kelompok Ascariasis (346,9 pg/L ± 135,9 pg/L) dan perbedaan antara kedua kelompok adalah signifikan (p=0,0361. Kesimpulan: Adanya infestasi cacing Ascaris lumbricoides di dalam usus, dapat menyebabkan gangguan absorpsi iodium, yang akhirnya dapat mengakibatkan rendahnya ekskresi iodium melalui urin (kadar UEI). Saran: Pada anak-anak yang berisiko tinggi terinfeksi Ascariasis, sebaiknya diberikan pengobatan antelmintik secara rutin secara rutin sebulan sekali. Program pengobatan dapat dilaksanakan secara swadaya oleh pihak sekolah, yaitu dengan membayar dua ribu rupiah per bulan, setiap murid akan mendapat obat cacing setiap bulannya dad puskesmas setempat. Distribusi kapsul iodiol pada anak sekolah sesuai dosis yang dianjurkan, sebaiknya terus dilaksanakan sampai endemisitasnya berkurang.

Item Type:Thesis (Masters)
Subjects:R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:Postgraduate Program > Master Program in Public Health
ID Code:14542
Deposited By:Mr UPT Perpus 1
Deposited On:16 Jun 2010 08:40
Last Modified:16 Jun 2010 08:40

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