EVALUASI EFEK ANALGESI PEMAKAIAN KETOPROFEN DAN KETOROLAK INTRAVENA PASCA TONSILEKTOMI

Abstract

Bockgound: Tonsillectomy procedure cause pain and various methods to control post tonsillectomy pain have been tried in the past. Ketorolac and ketoprofbn were used before tonsillectomy procedure in adults patients. Objective: To compare ketorolac with ketoprofen after elective tonsillectomy. Method: This experimental study was conducted at Central Operation Theatre Kariadi General Hospital from Ph December 2000 until 10 May 2001. Fourty adult patients age 16 - 40 years old, underwent elective tonsillectomy procedure with generd anesthesia MA . T-tesf independent statistics test was used in this study. A standard anesthesia was used. Patients received ketoprofen 100 nig LV, ketorolac 30 mg LV by infusion before induction of anaesthesia Bleeding times was measured before and during surgery. Pain was evaluated using a visual analogue scale ( VAS ). Pain, blood preasure, heart rate, respiratory rate and other adverse reaction was assesed at 0, 30, 60 minute, 4, 8, 12, 16, 20, 24 hour. Results: Ketorolac VAS value was better than ketoprofen (p < 0,05). Bleeding times was prolonged (p < 0,05) but normal. No difference in the incidence of other adverse reactio~is. Conclusions: Ketorolac is more effective than ketoprofen for analgesia after toiisillectoniy and less incidence of other adverese reactions. Latar belakang : Tonsilektomi menyebabkan nyeri. Penelitian terdahulu telah banyak dilakukan dalam mengurangi insiden nyeri. Obat ketorolak, ketoprofen diberikan sebelurn tonsil ektomi. Tujaan : Membandingkan efektivitas analgesi ketorolak dengan ketoprofen dalam tnengatasi nyeri pasca tonsilektotni. Metode: Penelitian dilakukan di instalasi bedah sentral RSUP Dr Kariadi, tanggal 1- 12-2000 hingga 1-5-2001, 40 orang penderita, usia 16-40 tahun, status EMI( ASA uji statistik independent t-test. Penderita dibagi menjadi dua, kelompok I (20) ketorolak 30 mg LV, kelompok It (20) Isetoprofen 100 mg I.V. Kuantitas nyeri dinilai menggimakan VAS (Visual analouee scale). Pengamatan tentang nyeri, tekanan darah, frekwensi denyut jantung, frekwensi napas dan efek samping that dilakukan pada menit ke 0, 30, 60 pasca sada•, jam ke 4, 8, 12,16, 20, 24. Ketorolak 30 mg LV memiliki efektivitas analgesi lebih baik ( p < 0,05 ), dibanding dengan ketoprofen 100 ing IV. Waktu perdarahan sebeluin dan selama operasi berbeda tidak bennakna Efek samping mai muntah hanya didapalkan 1 ( 5% ) patia masing-niasing kelompok. IKesitupulan : Ketorolak 30 mg I.V memiliki efektifitas analgesi lebih baik dibanding ketoprofen 100 mg IV. Efek samping tidak didipatkan