The Importance of solvent flow rate on the extraction of Andrographolide

Kumoro, A.C. and Hasan, M. (2004) The Importance of solvent flow rate on the extraction of Andrographolide. Journal of Tropical Medicinal Plant, 6 (2).

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Abstract

Andrographis paniculata NEES has been extensively used in traditional medicine and helps against fever, dysentery, diarrhoea, inflammation, and sore throat. Andrographolide, the main component of this plant was extracted from the leaves with supercritical carbon dioxide extractor at 40 ºC and 100 bar. The effect of supercritical solvent flow rate (ranging from 0.5 to 4 mL/min) on the extract yield and selectivity was studied. The extract yield increased with solvent flow rate. However further increase of solvent flow rate decreased the total yield. This may due to intraparticle diffusion resistance effect in the extraction process. The optimum solvent flow rate was 2mL/min.

Item Type:Article
Uncontrolled Keywords:andrographolide; CO2 extractor, flow rate; supercritical fluid extraction; yield
Subjects:T Technology > TP Chemical technology
Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions:Faculty of Engineering > Department of Chemical Engineering
Faculty of Engineering > Department of Chemical Engineering
ID Code:1312
Deposited By:Dr. Andri Kumoro
Deposited On:14 Oct 2009 16:10
Last Modified:14 Oct 2009 16:10

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