KADAR FRAKSI LEMAK DARAH PADA KEHAMILAN DENGAN PREEKLAMPSIA

Abstract

Objective: To investigate blood lipid fraction level in pregnancy with preeclampsia compared to normotensive pregnancy. Materials and method: The study design was cross-sectional, with a sample size of 62 patients. Of these, 31 had severe preeclampsia and 31 with normotensive pregnancy who met the inclusion criteria in Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine — Diponegoro University / Dr. Kariadi General Hospital Semarang, from January to July 2005. Data was statistically analyzed using t test, Chi-Square test, Mann-Whitney test, Pearson correlation and Spearman correlation, whenever appropriate. Statistical analyses were performed using SPSS for Windows version 11.5 to determine the relationship between blood lipid fraction level in severe preeclampsia and normotensive pregnancy. Results: There were differences in total cholesterol levels between severe preeclampsia (257.5(59.17) mg/dL) and normotensive pregnancy (224.0(40.83) mg/dL) with P = 0.02; in triglyceride levels between severe preedlampsia (284.1(120.99) mg/dL) and normotensive pregnancy (261.2(88.13) mg/dL) with P = 0.8; in LDL levels between severe preeclampsia (168.6(40.86) mg/dL) and normotensive pregnancy (151.9(28.03) mg/dL) with P = 0.07; and in HDL levels between severe preeclampsia (41.3(10.00) mg/dL) and normotensive pregnancy (52.4(10.75) mg/dL) with P = 0.001. Conclusion: The cholesterol level of pregnant women with preeclampsia was significantly higher than women with normotensive pregnancy. The triglyceride level of pregnant women with preeclampsia was not significantly different compared to women with normotensive pregnancy. The blood LDL level of women with normotensive pregnancy was significantly higher than pregnant women with preeclampsia. A negative correlation between blood HDL level with systolic and diastolic blood pressure was found. Tujuan : Meneliti kadar fraksi lemak darah pada kehamilan dengan preeklampsia dibanding kehamilan normotensi. Bahan dan cara : Metode penelitian adalah studi potong I intang (cross 'sectional study), pada 62 pasien dengan 31 preeklampsia berat dan 31 hamil normotensi yang memenuhi kriteria inklusi di Bagian / SMF Obstetri dan Ginekologi Fakultas Kedokteran Universitas Diponegoro / RS Dr. Kariadi Semarang, Sub Bagian Fetomaternal, pada januari sampai juli 2005. Data dianalisis secara statistik dengan menggunakan uji t test, Chi Squere, Mann-Whitney, korelasi pearson dan korelasi spearman selanjutnya dianalisa dengan SPSS for Window versi 11,5 untuk menentukan hubungan antara kadar fraksi lemak darah pada preeklampsia berat. Hasil : Didapatkan hasil yang berbeda kadar kolesterol total preeklampsia berat (257,5(59,17)mg/dL) dengan hamil normotensi (224.0 (40.83)mg/dL), P=0,02, cenderung berbeda kadar trigliserida preeklampsia berat (284,1(120,99)mg/dL) dan hamil normotensi (261,2(88,13)mg/dL), p=0,8, cenderung berbeda kadar LDL preeklampsia berat (168,6(40,86)Ing/dL) dan hamil normotensi (151,9(28,03)Ing/dL), p=0,07, berbeda kadar HDL preeklampsia berat (41,3(10,00)Ing/dL) dengan hamil normotensi (52,4(10,75)mg/dL), P=0,001. Simpulan : Kadar kolesterol darah ibu hamil dengan preeklampsia lebih tinggi secara bermakna dibanding ibu hamil normotensi. Kadar trigliserida darah ibu hamil dengan preeklampsia berbeda tidak bermakna dengan ibu hamil normotensi. Kadar LDL darah ibu hamil dengan preeklampsia berbeda tidak bermakna dengan ibu hamil normotensi. Kadar HDL darah ibu hamil normotensi lebih tinggi secara bermakna dibanding ibu hamil dengan preeklampsia. Dijumpai korelasi negatif antara kadar HDL darah dengan tekanan sistolik dan diastolik.