UJI BANDING EFEICTIVITAS DAN EFEK SAMPING GEL ASAM AZELAIK 20% DENGAN GEL KLINDAMISIN FOSFAT 1 % PADA AKNE PAPULOPUSTULOSA

WURYANTO , RUDI AGUNG (2004) UJI BANDING EFEICTIVITAS DAN EFEK SAMPING GEL ASAM AZELAIK 20% DENGAN GEL KLINDAMISIN FOSFAT 1 % PADA AKNE PAPULOPUSTULOSA. Masters thesis, Program Pendidikan Pasca sarjana Universitas Diponegoro.

[img]
Preview
PDF - Published Version
1780Kb

Abstract

Early and adequate treatment is very important to prevent permanent scar formation in papulopustular acne patients. Although the present topical antiacne treatments offer a high degree of efficacy but they also have potential side effects. The widespread use of topical antimicrobial agents is associated with the emergence of resistant strains of microorganism to some antibiotics such as to clindamycin . Azelaic acid is an antiacne medication recommended for the treatment of mild and moderate inflammatory acne without the risk of inducing bacterial resistance. This study compared the effectiveness and side effects of 20% azelaic acid gel with 1% clindamycin phosphate gel in the treatment of papulopustular acne patients. This study was a double —blind randomized controlled trial. Seventy patients were divided into two groups with block randomized allocations based on the grade of acne. Each of them received 20% azelaic acid gel or 1% clindamycin phosphate gel administered topically twice daily in the morning and evening for a 8-week period . Evaluation was conducted every two weeks. The assessment was done by assessing the reduction of the number of papules and pustules, also appearance of the side effects. The overall result of this study showed that there was no significant difference on the effectiveness of 20% azelaic acid gel and 1% clindamycin phosphate gel group in the treatment of papulopustular acne patients for 8 weeks. There was no significant difference regarding the side effects of both groups. Penatalaksanaan akne papulopustulosa secara dini dan tepat sangat penting karena jenis akne tersebut dapat mengakibatkan jaringan parut yang bersifat permanen. Meskipun obat akne topikal yang tersedia saat ini mempunyai efikasi tinggi namun potensial menimbulkan efek samping. Pemakaian antibiotika secara luas juga disertai munculnya strain mikroorganisme yang resisten terhadap beberapa antibiotika antara lain terhadap klindamisin . Asam azelaik merupakan salah satu obat antiakne topikal untuk pengobatan akne dengan peradangan ringan sampai sedang tanpa resiko menimbulkan resistensi bakteri . Tujuan penelitian untuk membandingkan efektivitas dan efek samping gel asam azelaik 20% dengan gel klindamisin fosfat 1% pada penderita akne papulopustulosa . Penelitian ini merupakan uji klinis acak terkontrol buta ganda. Pada 70 penderita akne papulopustulosa peserta dikelompokkan secara acak blok berdasarkan derajat akne. Setiap peserta mendapatkan pengobatan asam azelaik 20% atau klindamisin fosfat 1% digunakan 2 kali sehari pada pagi dan malam hari selama 8 minggu dengan evaluasi setiap 2 minggu. Penilaian yang dilakukan adalah menilai pengurangan jumlah papul / pustul dan adanya efek samping. I Hasil penelitian secara keseluruhan menunjukkan tidak terdapat perbedaan efektivitas yang bermakna antara gel asam azelaik 20% dengan klindamisin fosfat 1% pada pengobatan penderita akne papulopustulosa selama 8 minggu. Efek samping kedua kelompok pengobatan tidak berbeda secara bermakna.

Item Type:Thesis (Masters)
Subjects:R Medicine > R Medicine (General)
Divisions:Postgraduate Program > Master Program in Biomedical Science
ID Code:12380
Deposited By:Mr UPT Perpus 1
Deposited On:30 May 2010 16:32
Last Modified:30 May 2010 16:32

Repository Staff Only: item control page