FAKTOR - FAKTOR RISIKO YANG BERPENGARUH TERHADAP KEJADIAN AUTISME ( The risk factors of Autism )

MUHARTOMO, HEXANTO (2004) FAKTOR - FAKTOR RISIKO YANG BERPENGARUH TERHADAP KEJADIAN AUTISME ( The risk factors of Autism ). Masters thesis, Program Pendidikan Pasca sarjana Universitas Diponegoro.

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Abstract

Introduction: Infantile autism (so called autism) affects growth and development of children. Its incidence and prevalence tend to increase recently. The etiology of autisme is still unclear, it was suspected that there was no single etiological factor concerning with autism. Furthermore, there is no data available in Indonesia regarding this subyect. Method: A case-caontrol study was carried out to explore several risk-factors which may play significant role in autism Forty autistic children (36 males, 4 females, mean age 5,5 years) with to 40 normal developing children (32 males, 8 females, mean age 5,6 years) as control group were recruited in this study Historical data was obtained from their mothers and their medical record. Resuh: It was found that antenatal bleeding was a significant risk factor of autism (OR = 4,333; 95% CI = 1,271 — 14,777; p = 0,014), as well as birth asphyxia (OR = 4,111; 95% CI =1,037 — 16,295; p = 0,034). Meanwhile toxoplasmosis during pregnancy, hyperemesis gravidartun, low birth weight baby, birth trauma, febrile convulsion,.vaccination of Mumps, Measles, Rubella (MMR) were not risk factors. Conclusion: Since antenatal bleeding and birth asphyxia has an important role as risk factors of autisme, we suggest to improve antenatal care and process of delivery in the community. Latar belakang: Autisme merupakan penyebab penting dari gangguan tumbuhkembang anak yang insidensi maupun prevalensinya dewasa ini cenderung meninglcat. Sampai sekarang penyebab autisme belum diketahui dengan baik, namun tampalawa memang multi-faktorial. Penelitian ini bertujuan untuk mengetahui faktor-faktor risiko terhadap kejadian autisme, karena belum ada data tentang hal ini di Indonesia. Metoda: Dilakukan studi kasus kontrol dengan melibatkan 40 anak dengan autisme (36 lelaki, 4 perempuan, umur rata-rata 5,5 tahun) dan 40 anak lainnya sebagai kontrol (32 lelaki, 8 perempuan, umur rata-rata 5,6 tahun) untuk menganalisis 8 faktor risiko yang mungkin berpengaruh terhadap kejadian autisme. Data anamnesis diperoleh dari ibu kandung masing-masing anak di samping data dan catatan medik. Has& Didapatkan bahwa perdarahan antenatal merupakan faktor risiko autisme (OR = 4,333; 95% CI = 1,271 — 14,777; p = 0,014), demikian pula dengan asfiksia lahir (OR = 4,111; 95% CI =1,037 — 16,295; p = 0,034). Sedang toksoplasmosis waktu hamil, hiperemesis gravidarum, berat badan lahir rendah, trauma lahir, kejang demam, dan vaksinasi Mumps, Measles, Rubella (MMR) tidak terbukti sebagai faktor risiko autisme. Simpulan: : Karena perdarahan antenatal dan asfiksia lahir penting perannya dalam kejadian autisme, maka pengelolaan antenatal serta persalinan sangat penting untuk ditingkatkan.

Item Type:Thesis (Masters)
Subjects:R Medicine > R Medicine (General)
Divisions:Postgraduate Program > Master Program in Biomedical Science
ID Code:12341
Deposited By:Mr UPT Perpus 1
Deposited On:30 May 2010 14:29
Last Modified:30 May 2010 14:29

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